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TNF家族B细胞活化因子(B cell activating factor of the TNF family,BAFF)和增殖诱导配体(a proliferation inducing ligand,APRIL)具有较高的同源性。BAFF可分别与B细胞活化因子受体(BAFF-R)、B细胞成熟抗原(B cell maturation antigen,BCMA)和穿膜蛋白活化物(transmembrane activator and cyclophilin ligand interactor,TACI)3个受体结合,而APRIL则与受体BCMA、TACI结合发挥作用。近年来BAFF/APRIL及其受体的研究逐渐从自身免疫性疾病和实体肿瘤转移到了血液系统疾病中。本文对BAFF/APRIL及其受体在血液肿瘤性疾病,诸如慢性淋巴细胞白血病、急性淋巴细胞白血病、多发性骨髓瘤和淋巴瘤中的研究进展,包括BAFF/APRIL及其受体的功能、作用机制以及在治疗和预后中所起的作用等作一综述。
B family activating factor of the TNF family (BAFF) and proliferating inducing ligand (APRIL) have higher homology. BAFF binds to three receptors of B cell maturation antigen (BFF), B cell maturation antigen (BCMA) and transmembrane activator and cyclophilin ligand interactor (TACI) respectively, While APRIL binds to receptors BCMA and TACI. In recent years, studies of BAFF / APRIL and its receptors have gradually shifted from autoimmune and solid tumors to hematological disorders. This review focuses on the research progress of BAFF / APRIL and its receptors in hematological neoplastic diseases such as chronic lymphocytic leukemia, acute lymphoblastic leukemia, multiple myeloma and lymphoma, including the function and function of BAFF / APRIL and its receptors Mechanism and its role in treatment and prognosis.