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目的探讨卵巢储备功能正常的不孕症患者在长方案控制性超促排卵(COH)周期中卵泡发育晚期血清LH/降调节后Gn启动前的LH(LH晚/LH0)比值对体外受精-胚胎移植(IVF-ET)妊娠结局的预测价值。方法回顾性分析118例首次接受长方案COH且卵巢储备能力正常患者的临床资料,采用受试者工作特征曲线(ROC)筛选LH晚/LH0比值对妊娠结局预测的最佳阈值并根据该阈值进行分组即LH晚/LH0≤1组(A组)和LH晚/LH0>1组(B组),比较组间的临床参数,采用Logistic回归分析研究LH晚/LH0比值和临床妊娠之间的关系。结果长方案中LH晚/LH0比值最佳阈值为1.0,B组临床妊娠率明显高于A组,差异有统计学意义(χ2=19.34,P<0.01)。Logistic回归分析结果显示LH晚/LH0比值可以作为一个独立的临床妊娠结局的预测指标。结论对卵巢储备能力正常且采用长方案COH治疗的患者,LH晚/LH0比值>1.0者临床妊娠率明显增高,该比值对IVF妊娠结局具有一定的预测价值。
Objective To investigate the effect of LH (LH late / LH0) ratio before and after Gn-directed LHR on long-term controlled ovariectomy (COH) in patients with ovarian reserve (ESO) Predictive value of pregnancy outcomes in transplantation (IVF-ET). Methods The clinical data of 118 patients with long-term COH and normal ovarian reserve capacity were retrospectively analyzed. According to the receiver operating characteristic curve (ROC), the optimal threshold value of LH / LH0 ratio for predicting pregnancy outcome was screened and adjusted according to the threshold The groups were LH / LH0≤1 group (group A) and LH / LH0> 1 group (group B). The clinical parameters were compared between groups. Logistic regression analysis was used to investigate the relationship between LH / LH0 ratio and clinical pregnancy . Results The optimal threshold of LH / LH0 ratio was 1.0 in the long protocol. The clinical pregnancy rate in group B was significantly higher than that in group A (χ2 = 19.34, P <0.01). Logistic regression analysis showed that LH / LH0 ratio could be used as a predictor of independent clinical pregnancy outcomes. Conclusion In patients with normal ovarian reserve and long-term COH treatment, the clinical pregnancy rate is significantly higher in patients with LH / LH0 ratio> 1.0. This ratio has some predictive value for IVF pregnancy outcome.