运动预适应减轻一次性运动力竭大鼠心肌凋亡及其机制研究

来源 :东南国防医药 | 被引量 : 0次 | 上传用户：nimashabi2009

【摘要】

：

目的观察运动预适应对一次性运动力竭大鼠氧化应激水平、心肌细胞凋亡和内皮型一氧化氮合酶(eNOS)的影响,初步探讨其相关作用。方法建立一次性力竭运动模型,雄性SD大鼠采用随

【作者】

：

吕磊李瑶王永园金涛钟勇

【机构】

：

东部战区总医院（原南京军区南京总医院）干部心内科,东部战区总医院（原南京军区南京总医院）健康医学科

【出处】

：

东南国防医药

【发表日期】

：

2021年3期

【关键词】

：

运动预适应力竭运动凋亡内皮型一氧化氮合酶

【基金项目】

：

军委后勤保障部卫生局保健专项课题(18BJZ13),中国博士后科学基金(2018M633765)。

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论文部分内容阅读

目的观察运动预适应对一次性运动力竭大鼠氧化应激水平、心肌细胞凋亡和内皮型一氧化氮合酶(eNOS)的影响,初步探讨其相关作用。方法建立一次性力竭运动模型,雄性SD大鼠采用随机数字表法分成3组:安静对照组(不运动)、运动力竭组(持续运动直至力竭)和运动预适应组(大鼠在跑台上进行重复4次的间歇性运动),每组7只。HE染色观察光镜下大鼠的心肌组织改变,检测大鼠血清超氧化物歧化酶(SOD)活性、丙二醛(MDA)和一氧化氮(NO)含量。TUNEL染色法检测各组大鼠心肌细胞凋亡,Western blot法检测大鼠心肌内

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