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目的探讨呼吸道感染患儿血清降钙素原(PCT)、前白蛋白(PA)水平的变化及其与呼吸道感染性疾病间的关系。方法分别检测51例细菌感染患儿、54例病毒感染患儿和60例对照者的血清PCT、PA水平并进行统计学分析。结果细菌感染组血PCT、WBC水平均高于病毒感染组和对照组,PA水平均低于病毒感染组和对照组,差异有统计学意义(P<0.01)。血清PCT与WBC水平呈正相关(r=0.295,P<0.01);PA与WBC水平呈负相关(r=-0.210,P<0.05)。多元线性回归分析显示,血WBC(β=0.320,P<0.01)决定了9.2%的PCT变化。多元Logistic回归分析显示,校正年龄、性别因素后,高PCT、低PA水平仍是细菌感染组的危险因素。结论呼吸道细菌感染患儿血清PCT水平升高、PA水平降低,并与细菌感染密切相关。
Objective To investigate the changes of serum procalcitonin (PCT) and prealbumin (PA) in children with respiratory tract infection and their relationship with respiratory tract infectious diseases. Methods Serum levels of PCT and PA in 51 children with bacterial infection, 54 children with virus infection and 60 controls were detected and statistically analyzed. Results The levels of serum PCT and WBC in bacterial infection group were higher than those in virus infection group and control group, and the levels of PA in bacterial infection group were lower than those in virus infection group and control group (P <0.01). Serum PCT and WBC levels were positively correlated (r = 0.295, P <0.01); PA and WBC levels were negatively correlated (r = -0.210, P <0.05). Multiple linear regression analysis showed that blood WBC (β = 0.320, P <0.01) determined a PCT change of 9.2%. Multivariate logistic regression analysis showed that after age and gender were adjusted, high PCT and low PA levels were still risk factors for bacterial infection. Conclusion The serum PCT level is elevated and PA level is decreased in children with respiratory tract bacterial infection, which is closely related to bacterial infection.