D.Thienpont教授于1982年10月7日来沪讲学,兹将其部份内容,酮康唑(ketoconazole)治疗真菌病,整理如下。 体外试验 酮康唑具有抗真菌作用,其性质与氯苯咪唑(miconazole)相似。氯苯咪唑是一种咪唑类抗真菌药物,可局部应用、静脉滴注或口服。酮康唑的最低抑菌浓度报告各不相同,一般体外试验结果与体内应用不相适应,在某些情况下,体外试验常不能预示酮康唑在体内的活性,其它咪唑药物也有类似 Professor D. Thienpont came to Shanghai to give lectures on October 7, 1982. The following is a summary of ketoconazole treatment of fungal diseases. In vitro tests Ketoconazole has an antifungal effect similar to miconazole. Chlorbenzidine is an imidazole antifungal agent that can be topically applied, intravenously or orally. The minimum inhibitory concentrations reported for ketoconazole vary widely. In general, the results of in vitro tests are not compatible with those in vivo. In some cases, in vitro tests often do not predict the activity of ketoconazole in the body. Other imidazole drugs are also similar