瑞士科学家Breitenstein研究射血分数减低的冠少病病人服胺碘酮,减少猝死,因而降低死亡率。因为猝死可能为室性心律失常、冠状动脉血栓所触发,胺碘酮可能干预组织因子(TF)表达和血栓形成。因此,作者采用光化学损伤的鼠模型,体内观察胺碘酮(其血浆浓度与临床接近)TF活性降低和冠 Breitenstein, a Swiss scientist, studies amiodarone in patients with coronary heart disease with reduced ejection fraction to reduce sudden death and thus reduce mortality. Amiodarone may interfere with tissue factor (TF) expression and thrombosis because sudden death may be induced by ventricular arrhythmias and coronary thromboembolism. Therefore, the authors used photochemical damage in murine models, observed in vivo amiodarone (its plasma concentration and clinical close) TF activity decreased and the crown