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目的 揭示巨细胞病毒感染和急性心肌梗死之间的关系 ,并进一步探讨巨细胞病毒感染与冠心病有关的炎症介质之间的相关性。方法 用酶联免疫法 (ELISA)对急性心肌梗死急性期组(AMIa)、急性心肌梗死恢复期组 (AMIr)、陈旧性心肌梗死组 (OMI)、正常对照组分别进行血清巨细胞病毒 (CMV)特异性抗体IgG、IgM检测 ,并检测各组的血可溶性细胞间黏附分子 1(sICAM 1)、白介素 6 (IL 6 )、C反应蛋白 (CRP)。结果 (1)CMVIgG阳性率各组均高于正常对照组 (P <0 0 5 ) ,AMIa高于AMIr、OMI组 (P <0 0 5 ) ,后二者之间差异无显著性 (P >0 0 5 ) ;IgG浓度在四组中依次为AMIa、AMIr、OMI、正常对照组 (P <0 0 5 )。IgM阳性率AMIa高于其余 3组 (P <0 0 5 ) ,其余 3组之间差异无显著性。 (2 )炎症介质sICAM 1、IL 6病例组均高于正常组 (P <0 0 5 ) ,AMIa高于AMIr、OMI组 (P <0 0 5 ) ;CRP则仅AMIa高于AMIr、OMI、正常对照组 (P <0 0 5 )。AMIa组CMV感染组sICAM 1、IL 6、CRP显著高于非感染组 (P <0 0 5 ) ;OMI和AMIr组CMV感染组sICAM 1、IL 6也高于非感染组 (P <0 0 5 )。CMVIgG与CRP、sICAM 1、IL 6有很好的相关性。结论 (1)急性CMV感染与急性心肌梗死的发生有关 ,可能是后者的促发因?
Objective To reveal the relationship between cytomegalovirus infection and acute myocardial infarction and to further explore the correlation between cytomegalovirus infection and coronary heart disease-related inflammatory mediators. Methods Serum cytomegalovirus (CMV) was induced by acute myocardial infarction (AMIa), AMI (acute myocardial infarction) ) Specific IgG and IgM were detected. The levels of soluble intercellular adhesion molecule 1 (sICAM 1), interleukin 6 (IL 6) and C - reactive protein (CRP) in each group were determined. Results (1) The positive rate of CMVIgG in each group was higher than that in normal control group (P <0.05), AMIa was higher than that in AMIr and OMI group (P <0 05), there was no significant difference between the two groups (P> The concentrations of IgG in the four groups were AMIa, AMIr, OMI and normal control group (P <0.05). The positive rate of IgM in AMIa was higher than the other three groups (P <0.05), but there was no significant difference among the other three groups. (2) The levels of sICAM 1 and IL 6 in the inflammatory mediators were higher than those in the normal group (P <0.05), AMI was higher in the AMI and OMI groups (P <0.05) Normal control group (P <0 05). The levels of sICAM 1, IL 6 and CRP in CMV infection group were significantly higher than those in non-infection group (P <0.05) in AMIa group, and were higher in CMV infection group than those in non-infected group ). CMVIgG and CRP, sICAM 1, IL 6 have a good correlation. Conclusions (1) Acute CMV infection is related to the occurrence of acute myocardial infarction and may be the cause of the latter.