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目的:通过对伴2型糖尿病慢性牙周炎患者、不伴全身系统性疾病的慢性牙周炎患者以及健康对照组中TNF-α基因携带频率的分析,探讨病例组和对照组在该基因携带频率上的差异,并比较各组牙周临床指标和易感等位基因的关系。方法:采用牙周探针,对112例伴2型糖尿病慢性牙周炎患者(DM组)、99例单纯慢性牙周炎患者(CP组)以及健康对照组进行牙周临床指标检查和TNF-α-308基因型(TNF1/2)检测。采用SPSS13.0软件包对数据进行χ2检验和方差分析。结果:在DM组和轻中度CP组之间,轻中度DM组和重度CP组之间,重度DM组和轻中度CP组之间,重度DM组和重度CP组之间,TNF2的阳性基因型分布均有统计学差异(P<0.05)。携带等位基因TNF2的DM组和CP组的牙周探诊深度、临床附着丧失均分别显著高于只携带等位基因TNF1的DM组和CP组患者(P<0.05)。结论:携带TNF-α-308等位基因TNF2可能会增加人群牙周炎的易感性,并且在2型糖尿病和牙周炎协同作用过程中具有重要作用。
OBJECTIVE: To investigate the frequency of TNF-α gene in patients with chronic periodontitis with chronic type 2 diabetes mellitus, patients with chronic periodontitis without systemic systemic disease, and healthy controls. Frequency differences, and to compare the clinical periodontal indicators and susceptible alleles in each group. Methods: Periodontal probes were used to detect periodontal indexes and TNF-α in 112 patients with chronic periodontitis with type 2 diabetes mellitus (DM), 99 patients with chronic periodontitis (CP) and healthy controls. α-308 genotype (TNF1 / 2) detection. SPSS 13.0 software package was used to test the data and variance analysis. Results: Between DM group and mild to moderate CP group, between mild DM group and severe CP group, between severe DM group and mild to moderate CP group, between severe DM group and severe CP group, The positive genotype distribution was statistically significant (P <0.05). The depth of probing and clinical attachment loss in DM group and CP group carrying allele TNF2 were significantly higher than those in DM group and CP group carrying allele TNF1 only (P <0.05). CONCLUSION: TNF-α-308 allele TNF2 may increase susceptibility to periodontitis in humans and may play an important role in the synergistic effect of type 2 diabetes mellitus and periodontitis.