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目的探讨血清低密度脂蛋白胆固醇(LDL-C)与高密度脂蛋白胆固醇(HDL-C)比值与原发性高血压(以下简称高血压)分级的关系。方法随机抽取新诊断的高血压患者150例,分为1级、2级、3级高血压组,每组50例,另取50例血压正常者作为对照组,分别测定每组对象的血压、体质量、身高、血清甘油三脂(TG)、总胆固醇(TC)、LDL-C、HDL-C水平,计算LDL-C/HDL-C比值,并进行组间比较。各项血脂指标与血压水平及高血压分级的相关性采用Pearson相关分析。结果四组对象的血脂指标比较差异有统计学意义(P<0.05);Pearson相关分析显示,TG、TC、LDL-C水平、LDL-C/HDL-C比值分别与收缩压、舒张压、高血压分级呈正相关,HDL-C水平分别与收缩压、舒张压、高血压分级呈负相关,均P<0.05。LDL-C/HDL-C比值与高血压分级的相关系数的绝对值更接近1,相关性更强。结论血清LDL-C/HDL-C比值与原发性高血压分级的相关性较单项血脂指标更强。
Objective To investigate the relationship between the ratio of serum low density lipoprotein cholesterol (LDL-C) and high density lipoprotein cholesterol (HDL-C) and the grade of essential hypertension (hereinafter referred to as hypertension). Methods A total of 150 newly diagnosed hypertensive patients were randomly divided into 1, 2 and 3 hypertension groups, 50 cases in each group, and another 50 cases with normal blood pressure as the control group. The blood pressure, Body weight, height, serum triglyceride (TG), total cholesterol (TC), LDL-C and HDL-C levels were calculated. LDL-C / HDL-C ratio was calculated and compared between groups. Pearson correlation analysis was used to analyze the correlation between each lipid index and blood pressure and hypertension grade. Results There were significant differences in serum lipids between the four groups (P <0.05). Pearson correlation analysis showed that the levels of TG, TC, LDL-C and LDL-C / HDL-C were correlated with systolic blood pressure, There was a positive correlation between blood pressure classification and HDL-C levels were negatively correlated with systolic blood pressure, diastolic blood pressure and hypertension grade, respectively (P <0.05). The absolute value of the correlation coefficient between LDL-C / HDL-C ratio and hypertension grade was closer to 1, and the correlation was stronger. Conclusions The correlation between serum LDL-C / HDL-C ratio and essential hypertension classification is more significant than single blood lipid index.