论文部分内容阅读
微小RNA(microRNA,miRNA)是一类长度为19~25个核苷酸、细胞内源性表达的单链非编码RNA,其通过转录后抑制或mRNA降解调控靶基因的表达,进一步调控靶蛋白参与的信号通路。微小RNA-128(miR-128)是一种在神经系统中高表达的miRNA,在神经系统的发育及正常生理功能的维持中发挥重要作用,其异常表达与神经胶质瘤、阿尔茨海默病等疾病密切相关。近年研究证实,miR-128与多种肿瘤细胞的增殖、分化、凋亡、侵袭和转移有关。miR-128已成为与肿瘤诊断、治疗和预后相关的具有潜在价值的肿瘤标志物,并有望成为肿瘤治疗的新靶点。就miR-128与恶性肿瘤关系的研究进展进行综述。
MicroRNAs (miRNAs) are a class of single-stranded, non-coding RNAs that are 19-25 nucleotides in length and are endogenously expressed, which regulate the expression of a target gene through post-transcriptional repression or mRNA degradation, further regulating the target protein Signaling pathways involved. MicroRNA-128 (miRNA-128), a miRNA that is overexpressed in the nervous system, plays an important role in the development of the nervous system and the maintenance of normal physiological functions. Its aberrant expression is associated with glioma, Alzheimer’s disease Other diseases are closely related. Recent studies have confirmed that miR-128 and a variety of tumor cells proliferation, differentiation, apoptosis, invasion and metastasis. miR-128 has become a potential tumor marker associated with tumor diagnosis, treatment and prognosis, and is expected to become a new target of tumor therapy. The progress of research on the relationship between miR-128 and malignant tumors is reviewed.