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尼非卡兰是一种单纯的K+通道阻滞剂。有限的临床研究证实:对于急性冠状动脉综合征、围手术期的室性心动过速(简称室速)、心室颤动(简称室颤)以及难治性室速、室颤有良好的疗效。能提高心肺复苏早期效率;能提高心房颤动电复律的成功率,此外,对埋藏式心脏转复除颤器电风暴也有良好作用。主要不良反应为QT延长,有的会发生尖端扭转型室速。由于该药运用时间不长,其临床疗效有待进一步观察。
Neftekalan is a simple K + channel blocker. Limited clinical studies confirm: for acute coronary syndromes, perioperative ventricular tachycardia (VT), ventricular fibrillation (VF) and refractory VT, VF have a good effect. Can improve the early efficiency of cardiopulmonary resuscitation; can improve the success rate of cardioversion of atrial fibrillation, in addition, the impacted cardioverter defibrillator storm has a good effect. The main side effects of QT prolongation, and some may occur torsades de pointes ventricular tachycardia. As the drug is not used for a long time, its clinical efficacy remains to be further observed.