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目的探讨急性高原暴露时肺动脉压变化对体能的影响及机制。方法 2012年7~8月,以231名健康男性青年为研究对象,根据高原暴露情况分为平原组(n=135)、急进高原组(n=96),观察平均肺动脉压(MPAP)变化对体能(PWC170)的影响并分析生命体征、心功能指标变化在其中的作用。结果①急进高原组MPAP、右心室(RV)-Tei指数较平原组显著升高[MPAP:(23.07±6.85)mmHg vs(14.93±3.88)mmHg,P<0.01;RV-Tei:0.27±0.06 vs 0.19±0.05,P<0.01],PWC170较平原组显著降低[(807.86±133.22)kg·m/min vs(1003.33±168.11)kg·m/min,P<0.01];②急性高原暴露后肺动脉压增高组PWC170显著低于肺动脉压正常组[(726.97±102.47)kg·m/min vs(846.43±129.39)kg·m/min,P<0.01],RV-Tei显著高于肺动脉压正常组(0.31±0.07 vs0.25±0.05,P<0.01)。PWC170与MPAP呈负相关:R=-0.41,P<0.01;PWC170与RV-Tei呈负相关:R=-0.30,P<0.01。结论急性高原暴露时肺动脉压增高是体能下降的重要原因之一,其机制可能与肺动脉压增高导致右心功能降低有关。
Objective To investigate the effect and mechanism of pulmonary arterial pressure on physical function in acute plateau exposure. Methods From July to August 2012, 231 healthy male youth were enrolled and divided into plain group (n = 135) and acute plateau group (n = 96) according to altitude exposure. The changes of mean pulmonary artery pressure (MPAP) Physical (PWC170) effects and analyze the role of vital signs, cardiac function changes in which. Results ① The MPAP and RV-Tei index in acute plateau group were significantly higher than those in plain group [MPAP: (23.07 ± 6.85) mmHg vs (14.93 ± 3.88) mmHg, P <0.01; RV-Tei: 0.27 ± 0.06 vs 0.19 ± 0.05, P <0.01]. PWC170 was significantly lower than that of the plain group [(807.86 ± 133.22) kg · m / min vs (1003.33 ± 168.11) kg · m / min, P <0.01] The PWC170 in the elevated group was significantly lower than that in the normal pulmonary arterial pressure group [(726.97 ± 102.47) kg · m / min vs (846.43 ± 129.39) kg · m / min, P <0.01] ± 0.07 vs 0.25 ± 0.05, P <0.01). PWC170 was negatively correlated with MPAP: R = -0.41, P <0.01; PWC170 was negatively correlated with RV-Tei: R = -0.30, P <0.01. Conclusions The increase of pulmonary arterial pressure during acute plateau exposure is one of the important reasons of physical decline. The possible mechanism may be related to the decrease of right heart function caused by the increase of pulmonary arterial pressure.