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分别利用人和大鼠的原代肝细胞非程序ＤＮＡ合成试验（ＨＰＣ／ＵＤＳ），检测茶多酚（ＤＴＰ）对广西某肝癌高发区居民的饮用塘水浓缩物基因毒性的影响，结果发现：０．１０ｍｇ／ｍｌ的ＧＴＰ可抑制塘水浓缩物对大鼠肝细胞ＤＮＡ的损伤，而浓度为０．０５～０．５０ｍｇ／ｍｌ的ＧＴＰ可抑制塘水浓缩物对人肝细胞ＤＮＡ的损伤，且显示出一定的剂量—效应关系，这表明ＧＴＰ可抑制塘水存在的基因毒性物质，提示饮用绿茶对肝癌高发区的人群可能是有益的。
The effects of tea polyphenols (DTP) on the genotoxicity of drinking water concentrates of drinking water residents in a high incidence area of hepatocellular carcinoma in Guangxi were investigated using non-procedural DNA synthesis assay (HPC / UDS) of human and rat primary hepatocytes respectively. The results showed that: 0.10mg / ml of GTP could inhibit the DNA damage of rat liver cells by the concentration of water from the pond water, while GTP at the concentration of 0.05-0.50mg / ml inhibited the DNA damage of the human liver cells by the water concentrate, And showed a certain dose-response relationship, indicating that GTP can inhibit the presence of genotoxic substances in pond water, suggesting that drinking green tea may be beneficial for people with high incidence of HCC.