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The New International Land-Sea Trade Corridor (ILSTC), launched under the Belt and Road Initiative (BRI), is a trade and logistics passage that promotes the connectivity and cooperation between China's western region and ASEAN countries, and synergizes the BRI's two components of the Silk Road Economic Belt and the 21st Century Maritime Silk Road.1 At the third Lancang-Mekong Cooperation (LMC) Leaders' Meeting in August 2020, Chinese Premier Li Keqiang proposed the synergy between LMC and the ILSTC,2 which would further expand trade and cooperation on connectivity and promote coordinated development. The signing of a co-chairs' statement on cooperation ofsynergizing LMC and the ILSTC at this meeting has offered an important channel for countries in the region to enhance the depth and quality of their pragmatic cooperation in the process of creating a Lancang-Mekong community with a shared future. Amid the ever-growing economic and political uncertainties in the world today, Mainland Southeast Asia has taken on a more important role in China's neighborhood and global strategic layout, which makes the LMC-ILSTC synergy even more significant. It is necessary for all sides to innovate in their approach to cooperation, jointly address the new challenges brought about by the changing international environment, and enrich the content of Lancang-Mekong cooperation.