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目的:探讨利托君在先兆早产治疗中的效果。方法:回顾性分析60例先兆早产的孕妇随机分成盐酸利托君与硫酸镁2组。所有患者住院后给予卧床休息,并根据临床症状、查体、胎心监护,监测宫缩、宫颈管长度、宫口扩张、阴道流水等情况,了解治疗情况。在此基础上观察组给予利托君治疗,对照组给予硫酸镁治疗。比较应用利托君和硫酸镁后宫缩情况,起效时间、延长时间及新生儿情况。结果:经利托君治疗后,孕妇宫缩频率减少,孕期延长,保胎治疗成功,与对照组比较差异有显著性(P<0.05);观察组的新生儿出生体重和1min Apgar评分与对照组比较差异均有显著意义(P<0.05)。结论:利托君抑制子宫收缩起效快,治疗有效,保胎治疗成功率较高,能延长孕周,降低早产儿发生率,早产儿并发症发生率,值得在临床推广观察。
Objective: To investigate the effect of Rituximab in the treatment of threatened premature labor. Methods: A retrospective analysis of 60 pregnant women with threatened preterm birth was randomly divided into two groups: ritodrine hydrochloride and magnesium sulfate. All patients were hospitalized to give bed rest, and based on clinical symptoms, physical examination, fetal heart rate monitoring, monitoring of uterine contractions, cervical canal length, cervix expansion, vaginal water flow, etc., to understand the treatment. On this basis, the observation group was treated with ritodrine, while the control group was given magnesium sulfate. Compare the application of Rituximab and magnesium sulfate after contractions, onset time, prolonged time and newborns. Results: After treatment with ritodrine, the frequency of contractions in pregnant women decreased, the duration of pregnancy was prolonged, and the tocolytic therapy was successful. The difference was significant compared with the control group (P <0.05). The birth weight and 1-minute Apgar score in the observation group were significantly higher than those in the control group Group differences were significant (P <0.05). Conclusion: Rituxin inhibits uterine contractions rapidly and effectively, and has a high success rate of tocolytic treatment, which can prolong gestational age, reduce the incidence of premature children and the incidence of complications in premature infants. It is worthy of clinical promotion and observation.