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作者报告了口服去甲氧柔红霉素治疗6例原始细胞增多性难治性贫血(RAEB)的体会,RAEB_4例,RAEBt 2例,年龄73-85岁,均有贫血和粒细胞减少,骨髓原始细胞14-30%,均未化疗。方法:第一天50mg/m~2,分四次服,仅一天为一疗程。第14天用第二疗程,第21天再用一疗程,最多4疗程,然后每28天用一次25mg/m~2,用一年。结果:3例RAEB3-4疗程后CR,另3例2疗程后PR、CR和PR持续时间分别为60、20、45、8、38、15周,例1后20周没用药,复发后用药仍有效,例1,5至
The authors report the experience of oral decontimuramycin in the treatment of 6 cases of primary refractory anemia (RAEB), RAEB_4 cases, RAEBt 2 cases, aged 73-85 years, with anemia and neutropenia, bone marrow 14-30% of the original cells, no chemotherapy. Methods: The first day 50mg / m ~ 2, divided into four service, only one day for a course of treatment. Day 14 with the second course of treatment, the first 21 days and then a course of treatment, up to 4 courses, and then once every 28 days with 25mg / m ~ 2, with one year. Results: The CR, CR and PR of the other 3 cases after 2 courses of treatment were 60, 20, 45, 8, 38 and 15 weeks respectively after 3 courses of RAEB3-4 treatment, no medication after 20 weeks of cases 1, Still valid, cases 1, 5 to