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目的探讨糖尿病胃轻瘫(DGP)低血糖发生的相关因素,为临床低血糖的预防提供一定的指导,有利于血糖的控制。方法糖尿病胃轻瘫患者按住院期间是否发生低血糖,分为胃排空延迟(低血糖)组和胃排空正常(非低血糖)组。并检测体质量指数(BMI);空腹血糖(fastingplasma glucose,FPG);餐后2h血糖(PBG);糖化血红蛋白(HbA1c)。通过超声对受试者测量餐后不同时间胃窦部胃容积的变化确定胃排空情况,治疗过程中血糖监测采用指端末梢血测定(稳豪血糖仪,强生公司)。结果胃排空延迟组在性别、FPG(mmol/L)、HbA1c、PBG等各项与胃排空正常组比较,差异具有统计学意义(P<0.05)。而二组间年龄、BMI、HOMA-IR差异无统计学意义(P>0.05)。结论糖尿病胃轻瘫(胃排空延迟)是2型糖尿病患者发生低血糖的独立危险因素,因此应该加强24h动态血糖监测,及时预防、发现、纠正低血糖,减少因胃排空延迟引发低血糖导致的不良后果。
Objective To investigate the related factors of hypoglycemia in diabetic gastroparesis (DGP) and provide some guidance for the prevention of hypoglycemia in clinical practice, which is good for the control of blood glucose. Methods The patients with diabetic gastroparesis were divided into delayed gastric emptying (hypoglycemia) group and normal gastric emptying (non-hypoglycemia) group according to whether there was hypoglycemia during hospitalization. Body mass index (BMI), fasting plasma glucose (FPG), postprandial 2h blood glucose (PBG) and HbA1c were measured. Gastric emptying was determined by measuring the change of gastric volume in gastric antrum at different time points after the meal by ultrasound. Blood glucose was measured by fingertip in the course of treatment (Robinson Blood Glucose Meter, Johnson & Johnson). Results There was significant difference in gender, FPG (mmol / L), HbA1c, PBG, etc between the normal group and the normal gastric emptying group (P <0.05). There was no significant difference in age, BMI and HOMA-IR between the two groups (P> 0.05). Conclusions Diabetic gastroparesis (delayed gastric emptying) is an independent risk factor for developing hypoglycemia in patients with type 2 diabetes. Therefore, it is necessary to strengthen 24h dynamic glucose monitoring to prevent, detect and correct hypoglycaemia in time and to reduce hypoglycemia caused by delayed gastric emptying Caused by the adverse consequences.