冷球蛋白是血清中的一种遇冷沉淀的蛋白,此种蛋白首先由Wintrobe等在1933年发现,1947年由Lerner及Watson正式命名,有单一性和混合性两型。血清中如有冷球蛋白存在就称冷球蛋白血症。一般认为正常人血清申罕有冷球蛋白存在,即使存在含量也不多,但也有报告正常人血清中有较多冷球蛋白存在者。冷球蛋白多见于多发性骨髓瘤、巨球蛋白血症以及结缔组织疾病(尤其红斑性狼疮)、肾小球肾炎等,但其临床意义尚待阐明。国内尚无冷球蛋白测定及其与肾小球肾炎关系的报道,为了探讨这一问题,我们测定了30例正常人及30例肾脏病人的血中冷球蛋 Cryoglobulin is a cryoprecipitate in serum. This protein was first discovered by Wintrobe et al. In 1933 and formally named by Lerner and Watson in 1947. If cold globulins exist in the serum cryoglobulinemia. It is generally believed that there are few cold globulins in normal human serum, even if there is not much content, but there are also reports of the presence of more cryoglobulins in normal human serum. Cold globulin more common in multiple myeloma, macroglobulinemia and connective tissue diseases (especially lupus erythematosus), glomerulonephritis, but its clinical significance remains to be clarified. In our country, there is no report about the determination of cryoglobulins and their relationship with glomerulonephritis. To explore this problem, we measured the blood cryoglobulin in 30 normal subjects and 30 renal patients