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头颈部癌化疗始于50～60年代,80年代已确定其为癌治疗方法之一。近代化疗特征是从单剂转向多剂并用,并从晚期癌、复发癌治疗向初诊病例根治疗法的辅助疗法转变。头颈部癌也无例外。至今已研制出多种抗癌剂,获效佳。晚期头颈部癌特别是晚期头颈部鳞癌,仅用抗癌剂是不能根治的,尚待研制新药。头颈部有效抗癌药为氨甲喋吟(MTX)、博来霉素(LBM)、顺铂(CDDP)等。然而,单独应用极少能根治晚期癌,应与其他药或放疗并用。作者就CDDP
Head and neck cancer chemotherapy began in the 50s to 60s, and in the 1980s it was established as one of cancer treatment methods. The characteristics of modern chemotherapy are to change from single-agent to multi-agent, and change from the treatment of advanced cancer and recurrent cancer to the adjuvant treatment of newly diagnosed cases. Head and neck cancer is no exception. A variety of anti-cancer agents have been developed so far and have been effective. Advanced head and neck cancers, especially advanced head and neck squamous cell carcinomas, cannot be cured only with anti-cancer agents. New drugs are yet to be developed. Effective anti-cancer drugs for the head and neck are methotrexate (MTX), bleomycin (LBM), and cisplatin (CDDP). However, the use of rare drugs alone can cure advanced cancer and should be combined with other drugs or radiation therapy. Authors on CDDP