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[目的]为了发现醌类化合物中具有潜在修饰价值的抑菌先导化合物。[方法]采用菌丝生长速率法分别测定了10种醌类化合物a~j对番茄灰霉病菌和小麦赤霉病菌的室内抑菌活性。[结果]初步构效关系表明:化合物a~j对所测2种病原真菌均表现出不同程度的抑菌活性,其中菲醌(i)对番茄灰霉病菌表现出优于阳性对照霉灵(EC_(50)值为38.0 mg/L)的抑菌活性,其对应EC_(50)值为37.3 mg/L;茜素(b)和菲醌(i)对小麦赤霉病菌均表现出超过霉灵(EC_(50)值为76.1 mg/L)的抑菌活性,其对应EC_(50)值分别为18.6、5.3 mg/L。[结论]化合物b、c、d和i对番茄灰霉病菌和小麦赤霉病菌表现出较好的抑菌活性,初步拟定将这4种化合物作为下一步开发抑菌剂的先导化合物。
[Objective] To find the antibacterial lead compounds with potential modification value in quinone compounds. [Method] The mycelial growth rate method was used to determine the antibacterial activities of 10 quinones a ~ j against Botrytis cinerea and Fusarium graminearum. [Result] The preliminary structure-activity relationship showed that the compounds a ~ j showed different degrees of antibacterial activities against the two pathogenic fungi tested, and the phenanthrenequinone (i) showed superior activity to Botrytis cinerea than the positive control mycophenolate mofetil EC50 value of 38.0 mg / L), the corresponding EC 50 value was 37.3 mg / L; alizarin (b) and phenanthrenequinone (i) (EC 50 value was 76.1 mg / L). The corresponding EC 50 values were 18.6 and 5.3 mg / L, respectively. [Conclusion] The compounds b, c, d and i showed good antibacterial activities against Botrytis cinerea and Gibberella zeae. The four compounds were initially proposed to be the lead compounds for further development of bacteriostats.