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目的探讨微生态调节剂防治重症胰腺炎(AHNP)肠源性感染患者的临床疗效。方法选取2013年1月至2014年11月牡丹江医学院红旗医院收治的AHNP患者资料36例,按随机数字表法将患者分为观察组和对照组,各18例。对照组患者给予常规治疗,观察组患者在对照组基础上采用微生态调节剂进行治疗,比较两组患者的大肠埃希菌、肠球菌、双歧杆菌、乳酸菌菌落数以及肠道菌群失调的发生情况。结果治疗后1、2周,观察组患者的大肠埃希菌、肠球菌菌落数均明显低于对照组,双歧杆菌、乳酸杆菌均明显高于对照组,差异均有统计学意义(均P<0.05);观察组患者肠道菌群失调发生率为22.2%,明显低于对照组的88.9%,差异有统计学意义(P<0.05)。结论枯草杆菌二联活疫苗可抑制致病菌的过度繁殖,提高肠道细菌的效解能力,改善肠道内环境,最终达到恢复肠道微生态平衡的目的,利于患者康复,提高生活质量。
Objective To investigate the clinical efficacy of microecological regulator in prevention and treatment of intestinal infection of severe acute pancreatitis (AHNP). Methods A total of 36 patients with AHNP admitted to Hongqi Hospital of Mudanjiang Medical College from January 2013 to November 2014 were selected and divided into observation group and control group according to random number table. The patients in the control group were given routine treatment. The patients in the observation group were treated with the microbiological regulator on the basis of the control group. The numbers of colonies of Escherichia coli, Enterococcus, Bifidobacterium and lactic acid bacteria in the two groups were compared. What happened? Results After 1 and 2 weeks of treatment, the number of Escherichia coli and enterococci in the observation group was significantly lower than that of the control group, and Bifidobacterium and Lactobacillus were significantly higher than those in the control group (all P <0.05). The incidence of intestinal flora in the observation group was 22.2%, which was significantly lower than that in the control group (88.9%, P <0.05). Conclusion The dual Bacillus subtilis live attenuated vaccine can inhibit the overproduction of pathogenic bacteria, improve the efficiency of intestinal bacteria and improve the intestinal environment, and finally achieve the purpose of restoring intestinal microflora balance, which will benefit patients’ recovery and improve their quality of life.