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本文报道甘草甜素75和150mq/kg,每日1次共4天给小鼠ip结果,给药组脾重分别为102±21及123±27mg/10g,胸腺重分别为49±7和69±11mg/10g,与生理盐水对照组脾重70±14,胸腺39±9相比,有显著差异(p<0.01)。同样2个剂量组的甘甜素对0.1％四氯化碳(0.1ml10g)致中毒的小鼠,测定24小时后的血清SGPT及肝匀浆的GPT,发现本药能对抗四氯化碳对肝脏的急性中毒作用。此外,给小鼠ip甘草甜素75mg/Kg能显著提高小鼠对iV碳粒的廓清指
This article reports glycyrrhizin 75 and 150mq/kg, giving ip results once a day for 4 days. The spleen weight in the administration group was 102±21 and 123±27mg/10g respectively, and the thymus weight was 49±7 and 69 respectively. ±11mg/10g, compared with saline control group, spleen weight 70±14, thymus 39±9, there was a significant difference (p<0.01). In the same two dose groups of sweetin, 0.1% carbon tetrachloride (0.1ml 10g) poisoned mice, serum SGPT after 24 hours and liver homogenate GPT were measured. The drug was found to be able to fight carbon tetrachloride against the liver. The acute poisoning effect. In addition, mice given i glycyrrhizin 75mg/Kg can significantly improve mice’s clearance of iV carbon particles