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2008392 Chemokine receptor CXCR4 gene silencing with shRNA inhibits breast cancer metastasis to the lung in nude mice. ZHANG Mengxian(张孟贤), et al. Dept Oncol, Tongji Hosp, Tongji Med Coll, Huazhong Sci & Technol Univ, Wuhan 430030.Chin J Oncol 2008;30(5):325-329. Objective To construct a CXCR4 specific recombinant plasmid vector and study its inhibiting effect on invasion capacity in vitro of human breast cancer MDA-MB-231 cell line and its metastatic potential to the lung in nude mice.
2008392 Chemokine receptor CXCR4 gene silencing with shRNA inhibits breast cancer metastasis to the lung in nude mice. ZHANG Mengxian, et al. Dept Oncol, Tongji Hosp, Tongji Med Coll, Huazhong Sci & Technol Univ, Wuhan 430030. Chin J Oncol 2008; 30 (5): 325-329. Objective To construct a CXCR4 specific recombinant plasmid vector and study its inhibiting effect on invasion capacity in vitro of human breast cancer MDA-MB-231 cell line and its metastatic potential to the lung in nude mice.