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目的:探讨醒脑通脉颗粒对急性脑梗死的神经保护作用。方法:采用线栓法制作大鼠局灶性脑缺血再灌注模型,应用神经功能行为学评分、计算脑梗塞面积和水含量,评价醒脑通脉颗粒及尼莫地平的干预作用。结果:醒脑通脉颗粒小剂量(250mg/kg)、大剂量(1000mg/kg)组均能降低模型大鼠神经功能行为学评分(P<0.05、P<0.01),降低大鼠的脑水含量(P<0.01、P<0.05),减少模型大鼠脑组织脑梗死范围(P<0.01),较尼莫地平为优。结论:醒脑通脉颗粒对大鼠局灶性脑缺血再灌注损伤有保护作用。
Objective: To investigate the neuroprotective effect of Xingnao Tongmai Granule on acute cerebral infarction. METHODS: The model of focal cerebral ischemia-reperfusion in rats was established by thread embolism method. The neurological and behavioral scores were used to calculate the cerebral infarct size and water content. The interventional effects of Xingnao Tongmai Granules and nimodipine were evaluated. Results: Xingnao Tongmai Granules in low dose (250mg/kg) and high dose (1000mg/kg) groups can reduce neurological behavioral scores in model rats (P<0.05, P<0.01) and decrease the brain water of rats. Content (P<0.01, P<0.05) decreased brain infarct size in model rats (P<0.01) and was superior to nimodipine. Conclusion: Xingnao Tongmai Granule has a protective effect on focal cerebral ischemia-reperfusion injury in rats.