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目的探讨Oct-4蛋白在宫颈癌上的表达情况,明确其与宫颈癌患者临床资料的相关性及意义。方法应用免疫组化SP法,检测Oct-4在40例宫颈癌组织、30例宫颈上皮内瘤变(CIN)组织、10例正常宫颈组织的表达情况。结果 Oct-4蛋白在宫颈癌、CIN、正常宫颈的表达分别为92.5%(37/40)、36.7%(11/30)、0%(0/10),差异有显著性统计学意义(P<0.01)。宫颈癌上Oct-4蛋白的表达与患者的年龄、病理类型、TNM分期无明显相关性(P>0.05),而与宫颈癌的分化程度相关(P<0.05)。结论初步认为Oct-4蛋白可作为宫颈癌干细胞的表面标志物,为宫颈癌的靶向治疗提供研究方向。
Objective To investigate the expression of Oct-4 protein in cervical cancer and clarify its correlation with the clinical data of cervical cancer patients. Methods The expression of Oct-4 in 40 cases of cervical cancer, 30 cases of cervical intraepithelial neoplasia (CIN) and 10 cases of normal cervical tissue were detected by immunohistochemical SP method. Results The expression of Oct-4 protein in cervical cancer, CIN and normal cervix was 92.5% (37/40), 36.7% (11/30) and 0% (0/10), respectively, and the difference was statistically significant (P <0.01). There was no significant correlation between the expression of Oct-4 protein and the age, pathological type and TNM stage of cervical cancer (P> 0.05), but correlated with the differentiation degree of cervical cancer (P <0.05). CONCLUSIONS: Oct-4 protein may serve as a surface marker of cervical cancer stem cells and may provide a direction for targeted therapy of cervical cancer.