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目的观察抗矽口服液辅助治疗矽肺患者的临床疗效。方法选择矽肺患者148例(Ⅰ期97例、Ⅱ期42例、Ⅲ期9例),随机分成治疗组和对照组2组,均常规给予抗炎、止咳、平喘治疗。治疗组在常规治疗的基础上,使用抗矽口服液10ml,2次/d,每周服药6 d,用药3个月,间隔1个月后重复给药3个月。对比临床症状和超氧化物歧化酶(SOD)活力。结果矽肺患者咳嗽、咳痰、胸痛、呼吸困难4项临床症状明显改善(P<0.05)。治疗后治疗组的SOD活力显著高于对照组,差异有统计学意义。结论采用中西药联合治疗矽肺的方法有利于提高药物疗效,减轻患者临床症状,值得推广使用。
Objective To observe the clinical efficacy of anti-Si oral liquid in the treatment of patients with silicosis. Methods A total of 148 patients with silicosis (97 in stage Ⅰ, 42 in stage Ⅱ, and 9 in stage Ⅲ) were randomly divided into treatment group and control group, and were given anti-inflammatory, cough-relieving and antiasthmatic treatment routinely. The treatment group on the basis of conventional treatment, the use of anti-silicon oral solution 10ml, 2 times / d, taking 6days a week, medication for 3 months, one month after the interval repeated dosing for 3 months. Clinical symptoms and superoxide dismutase (SOD) activity were compared. Results The clinical symptoms of cough, sputum, chest pain and dyspnea were significantly improved in patients with silicosis (P <0.05). After treatment, the SOD activity of the treatment group was significantly higher than that of the control group, the difference was statistically significant. Conclusion The combination of Chinese and Western medicine treatment of silicosis is conducive to improve the efficacy of drugs to reduce the clinical symptoms of patients, it is worth promoting the use of.