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丙型肝炎病毒(hepatitis C virus,HCV)属于黄病毒科(Flaviviridae),其基因组为单股正链RNA,全长9.6 kb。HCV基因组只有一个开放读码框,编码一个含3 010~3 033个氨基酸残基的大多聚蛋白,经细胞信号肽酶和病毒蛋白酶加工后产生HCV结构蛋白(core、E1、E2和p7)和非结构蛋白(NS2、NS3、NS4A、NS4B、NS5A、NS5B)。HCV感染不仅可引起急性丙型肝炎和慢性丙型肝炎(chronic hepatitis C,CHC),且与肝纤维化及肝细胞癌
Hepatitis C virus (HCV) belongs to the genus Flaviviridae and its genome is single-stranded positive-stranded RNA, which is 9.6 kb in length. The HCV genome has only one open reading frame and encodes a large majority of polyproteins containing 3,010 to 3,033 amino acid residues. After being processed by cellular signal peptidase and viral protease, the HCV structural proteins (core, E1, E2 and p7) and Non-structural proteins (NS2, NS3, NS4A, NS4B, NS5A, NS5B). HCV infection can not only cause acute hepatitis C and chronic hepatitis C (CHC), and with liver fibrosis and hepatocellular carcinoma