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目的探讨健康体检人群中,14种食物不耐受的检测现状及其与人体泌尿结石的相关性。方法选取2011年1月至2012年12月某综合医院健康管理中心进行食物不耐受检测者490例,采用酶联免疫吸附法检测血清14种食物过敏原特异性IgG抗体,采用χ2检验比较食物不耐受不同程度分级及每一种食物不耐受阳、阴性组人体泌尿结石的情况,应用非条件Logistic回归模型进行泌尿结石的多因素分析。结果按IgG抗体阳性率高低排序,前三位分别为鸡蛋(32.45%)、螃蟹(27.96%)、牛奶(12.65%)。存在食物不耐受的检测者中,轻、中、重度食物不耐受分别占67.15%、24.09%、8.76%,中、重度不耐受多见于鸡蛋、牛奶,其次为螃蟹和鳕鱼。在控制收缩压、年龄、体重、红细胞等混杂因素的影响后,食物不耐受是泌尿结石的保护因素(OR=0.965,95%CI:0.943~0.987),且存在一定的剂量—反映关系,食物不耐受程度越重,结石阳性率越低(χ2=7.191,P=0.007);牛奶、鸡蛋两种食物不耐受阳性组的泌尿结石阳性率均显著低于不耐受阴性组(χ2=5.370,P=0.020;χ2=6.696,P=0.010),其余12种食物不耐受阳性组与不耐受阴性组的泌尿结石阳性率差异均无统计学意义。结论食物不耐受情况较为普遍。食物不耐受并非加重人体泌尿结石的发病率,而是与泌尿结石呈负相关,这可能与人们因食物不耐受而限制食物的摄取有关联。
Objective To investigate the detection status of 14 kinds of food intolerance and its correlation with urinary calculus in healthy people. Methods From January 2011 to December 2012, 490 cases of food intolerance were detected in a general hospital health management center. Serum 14 kinds of food allergen-specific IgG antibodies were detected by enzyme-linked immunosorbent assay (ELISA), and compared with χ2 test Intolerance to varying degrees of grading and each food intolerance of positive and negative group of urinary stones, the use of non-conditional Logistic regression model for multiple urinary stones analysis. The results were ranked according to the positive rate of IgG antibodies, the first three were eggs (32.45%), crabs (27.96%), milk (12.65%). Among the test subjects with food intolerance, 67.15%, 24.09% and 8.76% of light, moderate and severe food intolerance, respectively. The moderate and severe intolerance was more common in eggs and milk, followed by crabs and cod. Food intolerance was the protective factor of urinary stones (OR = 0.965, 95% CI: 0.943 ~ 0.987) after controlling the influence of confounding factors such as systolic blood pressure, age, body weight and erythrocytes, and there was a dose- The higher the degree of food intolerance, the lower the positive rate of stones (χ2 = 7.191, P = 0.007); the positive rates of urinary stones in both milk and egg-intolerant groups were significantly lower than those in the negative group (χ2 = = 5.370, P = 0.020; χ2 = 6.696, P = 0.010). There was no significant difference in the positive rates of urinary stones among the other 12 food-intolerant and non-intolerant groups. Conclusion Food intolerance is more common. Food intolerance does not increase the incidence of urolithiasis in humans, but negatively correlates with urolithiasis, which may be related to people’s restriction of food intake due to food intolerance.