目的研究胃炎不同取材部位和方法,对胃黏膜幽门螺杆菌(Helicobacter pylori,HP)检出的影响。方法在胃镜检查中,对500例患者分别在隆起糜烂病灶和胃窦幽门附近非隆起病灶活检钳取黏膜标本,分别行快速尿素酶实验(HPUT)和隆起糜烂病灶黏膜病理切片银染色检测HP。结果经HPUT实验检测,隆起病灶粘膜的HP阳性385例(77.0%),非隆起病灶黏膜的HP检出296例阳性(59.2%),两者阳性率比较差异有统计学意义(χ2=36.4621,P<0.001);在500病例中,完成隆起病灶黏膜病理切片银染色检测者325例,发现HP感染238例(73.23%),病理检测法与HPUT检测法所得阳性率比较无显著性差异(P>0.05)。结论对于有隆起糜烂病灶的患者进行HP检测时,应尽可能取隆起病灶标本检测HP,以提高阳性率和准确率。 Objective To study the effect of different regions and methods of gastritis on the detection of Helicobacter pylori (HP) in gastric mucosa. Methods In gastroscopy, mucosa specimens were taken from 500 patients with undifferentiated lesions on the erosive erosive lesion and non-erected lesions near the pylorus of the antrum respectively. HP was detected by silver staining in fast urease test (HPUT) and mucosal pathological examination of the erosive erosive lesions. Results After HPUT test, 385 cases (77.0%) were positive for HP in the mucosa of the uplift and 296 cases (59.2%) were positive in the non-mucosal mucosa of the non-uplift, the positive rates of the two were statistically significant (χ2 = 36.4621, (P <0.001). In 500 cases, 325 cases of pathologically detected mucosal lesions of silver staining were found in 325 cases and 238 cases (73.23%) were infected with HP. There was no significant difference in the positive rates of pathological examination and HPUT detection (P > 0.05). Conclusion For HP patients with elevated erosive lesions, hemorrhagic lesions should be taken as far as possible to detect HP, in order to improve the positive rate and accuracy.