目的了解胎儿肿瘤的产前超声检出情况,分析失访率及失访原因,以便加强对胎儿肿瘤的产前诊断工作。方法回顾性分析2 180例胎儿肿瘤的临床资料,将孕妇按年龄分为<25岁、25~35岁、>35岁3个年龄组;将受检胎儿按孕周分为<18周、18~24周、24~30周、30~36周、36~41周5个组,比较不同年龄组及不同孕龄组胎儿肿瘤的检出率。根据随访情况把研究对象分为失访组和随访组,分析失访率及失访原因。结果胎儿肿瘤的总检出率为1.32%(2 180/164 783),从2011-2015年检出率分别为1.10%、1.23%、1.34%、1.43%、1.47%。胎儿肿瘤检出率在各年龄组间的差异无统计学意义(P>0.05),在各孕龄组间的差异有统计学意义(P<0.05),多发生在孕中晚期。胎儿肿瘤总失访率32.98%(719/2 180),从2011-2015年失访率依次为41.82%、37.70%、32.13%、29.45%、28.22%。76.63%的失访原因是患者拒绝尸检。结论 2011-2015年胎儿肿瘤的年检出率呈增长趋势。胎儿肿瘤大多发生于中晚孕期,和孕妇年龄无关,建议加强晚孕期产前检查。 Objective To understand the prenatal ultrasound detection of fetal tumors, analyze the rate of follow-up and the reasons for the loss of follow-up in order to strengthen the prenatal diagnosis of fetal tumors. Methods The clinical data of 2180 cases of fetal tumors were retrospectively analyzed. The pregnant women were divided into three groups of age <25 years old, 25-35 years old and> 35 years old. The fetuses were divided into <18 weeks 24 weeks, 24-30 weeks, 30-36 weeks and 36-41 weeks. The detection rate of fetal tumors in different age groups and gestational age groups was compared. According to the follow-up situation, the subjects were divided into the lost group and the follow-up group to analyze the rate of lost and the reason of losing. Results The overall detection rate of fetal tumors was 1.32% (2 180/164 783). The detection rates were 1.10%, 1.23%, 1.34%, 1.43% and 1.47% respectively from 2011 to 2015. Fetal tumor detection rate in all age groups was no significant difference (P> 0.05), in the gestational age group differences were statistically significant (P <0.05), occurred in the second trimester of pregnancy. The total rate of fetal tumor loss was 32.98% (719/2 180). The rate of follow-up from 2011 to 2015 was 41.82%, 37.70%, 32.13%, 29.45% and 28.22%, respectively. 76.63% of the patients lost the reason for the refusal of autopsy. Conclusion The annual detection rate of fetal tumors in 2011-2015 showed an increasing trend. Fetal tumors occur mostly in the middle and late pregnancy, and has nothing to do with the age of pregnant women, it is recommended to strengthen prenatal care during the first trimester.