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目的:观察多囊卵巢综合征(PCOS)不孕患者采用两种方法预处理后对促排卵的临床疗效。方法:将89例P-COS患者随机分成两组,甲组50例应用达英-35预处理2个周期后,予克罗米芬(CC)或克罗米芬+尿促性素(HMG)促排卵;乙组49例应用达英-35预处理3个周期后,同法促排卵。观察治疗前后内分泌指标的变化以及应用促排卵药物剂量及临床妊娠率。结果:两组不同方法预处理后LH、T较治疗前均有显著下降,两者间差异有统计学意义(P<0.05);所用促排卵药物剂量(HMG)及治疗天数,两组间差异有统计学意义(P<0.05);妊娠率两组间差异无统计学意义(P>0.05)。结论:应用达英-35预处理2个周期后促排卵治疗所用药物剂量少,治疗天数少,排卵率高,而不影响妊娠率。
Objective: To observe the clinical efficacy of ovulation induction after pretreatment by two methods in patients with polycystic ovary syndrome (PCOS) infertility. Methods: A total of 89 patients with P-COS were randomly divided into two groups. 50 cases in group A were given clomiphene citrate (CC) or clomiphene citrate (HMG) for ovulation after pretreatment with da-35 for 2 cycles. Group B, 49 cases of up to -35 pretreatment three cycles, with the law to promote ovulation. Observed before and after treatment changes in endocrine indicators and the application of ovulation induction dose and clinical pregnancy rate. Results: After pretreated by two different methods, LH and T decreased significantly compared with those before treatment, the difference was statistically significant (P <0.05); the dosage of ovulation induction (HMG) and the number of days of treatment, the difference between the two groups There was statistical significance (P <0.05). There was no significant difference in pregnancy rate between the two groups (P> 0.05). Conclusion: The application of up to -35 pre-treatment of ovarian cycles after 2 cycles of ovulation treatment with less dosage, fewer days of treatment, ovulation rate, without affecting the pregnancy rate.