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目的 :比较血清爱泼斯坦 -巴尔病毒 (EBV )抗体滴定度测定与癌组织 EBV基因组检测对鼻咽癌(NPC)的诊断价值。方法 :146例患者采用双盲法测定血清 EBV- VCA- Ig A、EBV- EA- Ig A和活检组织 EBV- DNA(PCR)。全组病例按活检病理检查结果分为 :NPC组 ,非 NPC组 (对照组 )。结果 :NPC组中 EBV- DNA(PCR) ,EBV- VCA- Ig A和 EBV- EA- Ig A的阳性率分别为 90 .8% ,75 .0 %和 2 6 .3% ;对照组上述检测的阳性率分别为2 .9% ,38.6 %和 2 .9%。其差别均有显著性意义 (P<0 .0 0 5 )。结论 :EBV- DNA(PCR)检测对 NPC的诊断具有灵敏度高和特异性强的特点。
Objective: To compare the diagnostic value of serum Epstein-Barr virus (EBV) antibody titer and EBV genome detection in nasopharyngeal carcinoma (NPC). METHODS: Serum EBV-VCA-Ig A, EBV-EA-Ig A and biopsy EBV-DNA (PCR) were determined in 146 patients by double-blind method. According to biopsy results, the whole group of patients were divided into NPC group and non-NPC group (control group). Results: The positive rates of EBV-DNA (PCR), EBV-VCA-Ig A and EBV-EA-Ig A in NPC group were 90.8%, 75.0% and 26.3% The positive rates were 2.9%, 38.6% and 2.9% respectively. The difference was significant (P <0.05). Conclusion: The detection of EBV-DNA (PCR) has the characteristics of high sensitivity and specificity for the diagnosis of NPC.