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Randic 提出涉及有机分子拓朴信息的连接性指数后,Kier 等通过计算各种指数发现与各种测得的物理性质之间有一定的关系,可将它作为反映分子结构的参数而用于定量构-效关系的研究。正丁醇-水分配系数的对数log P 是一种可测物理
After Randic proposed connectivity indices involving topological information of organic molecules, Kier et al. Found a relationship between the various measured physical properties by calculating various indices and can be used as a parameter to reflect molecular structure in quantification Study on Structure - Effectiveness. The logarithm of n-butanol-water partition coefficient log P is a measurable physical