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目的观察艾塞那肽对高原地区血糖控制不佳的2型糖尿病患者的疗效。方法选择二甲双胍、磺脲类药物或胰岛素治疗后血糖控制不佳的2型糖尿病患者18例,在原有治疗方案的基础上加用艾塞那肽注射液治疗3个月,监测患者空腹血糖(FBG)、餐后2h血糖(2hPBG)、糖化血红蛋白(HbA1c)、三酰甘油(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、体质量等指标的变化。结果艾塞那肽治疗3个月后,患者FBG、2hPBG、HbA1c、体质量指数,血脂TG、TC、LDL-C水平均较治疗前降低(P<0.05)。结论艾塞那肽能有效控制高原地区2型糖尿病患者血糖,降低患者体质量指数,并改善血脂水平。
Objective To observe the effect of exenatide on type 2 diabetes patients with poor glycemic control in the plateau area. Methods 18 patients with type 2 diabetes mellitus with poor glycemic control after metformin, sulfonylurea or insulin therapy were treated with exenatide injection for 3 months on the basis of the original treatment plan. The fasting blood glucose (FBG) (2hPBG), HbA1c, TG, TC, HDL-C and LDL-C in postprandial period were measured. , Body weight and other indicators of change. Results Exenatide treatment for 3 months, the patients FBG, 2hPBG, HbA1c, body mass index, serum lipids, TC, LDL-C levels were lower than before treatment (P <0.05). Conclusion Exenatide can effectively control blood glucose in patients with type 2 diabetes mellitus in the plateau, reduce body mass index, and improve blood lipid levels.