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目的:系统评价血管扩张剂治疗突发性聋的疗效和安全性。方法:运用系统评价的方法,计算机检索Cocharane图书馆,PubMed,EmBase,ISI,中国生物医学文献数据库,中国学术期刊全文数据库,VIP中文科技期刊全文数据库和万方数据库。纳入中外文血管扩张剂治疗突发性聋的随机对照试验(RCT)。按Cochrane系统评价标准评价纳入研究质量,对同质研究采用RevMan软件进行Meta分析,对不能进行Meta分析的数据,只进行描述性的定性分析。结果:共纳入28个RCT。Meta分析结果提示血管扩张剂与安慰剂对照的7个试验中,未发现血管扩张剂疗效优于安慰剂;血管扩张剂与血管扩张剂比较的14个试验中,未发现哪种血管扩张剂更有效;血管扩张剂与其他治疗对比的9个试验中,未发现血管扩张剂优于其他治疗方法。结论:血管扩张剂治疗突发性聋的疗效仍不清楚,由于上述的结论基本来自单个研究,研究质量参差不齐,大多数研究样本量小,因此使用结论时必须谨慎。目前尚无足够的证据证明哪种药物更有效,期待开展更多高质量、大样本、长期随访的RCT,以提供更可靠的证据。
Objective: To evaluate the efficacy and safety of vasodilators in the treatment of sudden deafness. Methods: Using systematic reviews, we searched the Cocharane Library, PubMed, EmBase, ISI, Chinese Biomedical Literature Database, Chinese Academic Journal Full-text Database, VIP Chinese Scientific and Technical Periodicals Full Text Database and Wanfang Database. A randomized controlled trial (RCT) was included in the treatment of sudden deafness by Chinese and foreign vasodilators. The quality of the included studies was assessed according to the Cochrane systematic review criteria. Meta-analysis was performed using the RevMan software for homogeneous studies, and only descriptive qualitative analyzes of data that could not be Meta-Analyzed. Results: A total of 28 RCTs were included. Meta-analysis showed no effect of vasodilator over placebo in 7 trials of vasodilators vs placebo; no vasodilator was found in 14 of the 14 trials comparing vasodilators and vasodilators Vasodilators compared with other treatments in 9 trials, vasodilators were not found to be superior to other treatments. CONCLUSIONS: The efficacy of vasodilators in treating sudden deafness remains unclear. Since the above conclusions are basically from a single study, the quality of the studies is variable and the majority of the studies are small, care must be taken when using the conclusions. There is not enough evidence to prove which drugs are more effective and we are looking forward to more RCTs of high quality, large sample and long-term follow-up to provide more reliable evidence.