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目的探讨乙型肝炎病毒(HBV)母婴阻断的临床效果及影响因素分析。方法选取建德市第一人民医院2012年1月—2015年6月收治的乙肝表面抗原(HBs Ag)阳性母亲及其所生产的婴幼儿482例,收集母亲的年龄、乙肝e抗原(HBe Ag)状态、乙肝病毒基因(HBV-DNA)载量及婴幼儿的Apgar评分、分娩方式、喂养方式等情况。结果在482例母亲所生的婴幼儿中,乙肝母婴阻断成功率为95.65%。将乙肝母婴阻断成功461例为成功组,未成功21例为未成功组,两组患者分娩方式、喂养方式及Apgar评分比较,差异无统计学意义(P>0.05);成功组患者母体感染状态、HBV-DNA载量情况优于未成功组(P<0.05)。多因素logistic回归分析结果显示,HBe Ag阳性和HBV-DNA高载量是HBV母婴阻断失败的影响因素(P<0.05)。结论 HBe Ag阳性和HBV-DNA高载量是HBV母婴阻断失败的主要影响因素。
Objective To investigate the clinical effect and influencing factors of hepatitis B virus (HBV) Methods 482 HBsAg positive mothers and their infants born from January 2012 to June 2015 in Jiande First People’s Hospital were collected and their age, HBe Ag ) Status, hepatitis B virus (HBV-DNA) load and infants Apgar score, mode of delivery, feeding methods and so on. Results Among 482 mothers born infants and toddlers, the successful rate of blocking hepatitis B was 95.65%. There were no significant differences in the delivery mode, feeding mode and Apgar score between the two groups (P> 0.05). In the successful group, 461 cases were successful, 46 cases were unsuccessful and 21 cases were unsuccessful. Infection status, HBV-DNA load was better than the unsuccessful group (P <0.05). Multivariate logistic regression analysis showed that HBeAg-positive and HBV-DNA high load were the factors influencing the failure of HBV maternal and neonatal blockade (P <0.05). Conclusion HBeAg-positive and HBV-DNA high load are the main factors affecting the failure of HBV maternal and neonatal blockade.