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200名HBV易感者分二组分别接种Amgen公司生产的乙肝酵母基因疫苗(G苗)和Smith公司疫苗(s苗).4年后24.59％的免疫者抗-HBs滴度下降到10mlU/ml以下。抗-HBs保护水平持续时间取决于3针免疫后最高滴度水平。抗-HBs>1000mlU/ml者,4年后G苗仍100％大于10mlU/ml,S苗则为97.6％,而抗-HBs在10～100mIU/ml之间者,4年后皆<10mIU/nl。抗-HBs滴度随时间延长呈指数曲线下降,首次免疫后前24个月几乎下降了全部滴度的80％,以后下降缓慢,抗-HBs滴度水平不同组其回归直线斜率相似,表明抗-HBs滴度下降百分率与最初浓度无关。在此基础上制出标准回归直线,并用做平行线的方法推测个体加强免疫时间。
200 HBV-susceptible individuals were inoculated with Amgen-produced hepatitis B yeast vaccine (G) and Smith (s) vaccine in two groups, and the anti-HBs titers dropped to 10 mlU / ml after 24.59% of immunizations the following. The duration of anti-HBs protection depends on the highest titer level after 3-pin immunization. Anti-HBs> 1000mlU / ml, 4 years after the G seedlings still 100% greater than 10mlU / ml, S seedlings was 97.6%, and anti-HBs in the 10 ~ 100mIU / ml between 4 years after all <10mIU / nl. The anti-HBs titer decreased exponentially with time, almost 80% of the total titer decreased in the first 24 months after the first immunization, and then decreased slowly. The slope of the regression line of anti-HBs titer was similar in different groups, indicating that the anti- The percentage reduction in HBs titres was independent of the initial concentration. On this basis, a standard regression line was made, and used as a parallel line method to speculate that individuals to strengthen the immune time.