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胰腺癌恶性程度高、预后极差。目前其发生、发展、转移等机制尚不明确,一直是该领域的研究热点和难点之一。本文概述了25年来从事胰腺癌的相关基础与临床研究,即从多克隆抗体到单克隆抗体,从癌基因、抑癌基因到转移抑制基因的研究;从组织到细胞,从动物模型到人体的基础研究;以及胰腺癌患者的早期诊断、药物治疗、辅助治疗的临床研究,为进一步的深入研究提供新思路。
Pancreatic cancer has a high degree of malignancy and a very poor prognosis. At present, the mechanism of its occurrence, development and transfer is still not clear and has always been one of the hot spots and difficulties in this field. This article provides an overview of the basic and clinical research that has been conducted in pancreatic cancer for more than 25 years, from polyclonal antibodies to monoclonal antibodies, from oncogenes to tumor suppressor genes to metastasis suppressor genes; from tissues to cells, from animal models to humans Basic research and early diagnosis of pancreatic cancer patients, drug treatment, adjuvant clinical research, provide further ideas for further research.