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目的比较阿立哌唑与氯氮平对体重及血糖的影响。方法对单服阿立哌唑或氯氮平的精神分裂症患者于服药前后测定体重及血糖的变化。结果服用阿立哌唑4周后体重有所增加(P<0.05),血糖水平无明显变化。服用氯氮平后体重(P<0.01)、血糖(P<0.05)于第4周明显增加,但体重有逐渐升高的趋势。结论阿立哌唑与氯氮平均可导致体重增加,氯氮平可引起血糖升高,而阿立哌唑对血糖无影响。
Objective To compare the effects of aripiprazole and clozapine on body weight and blood glucose. Methods The changes of body weight and blood glucose were determined before and after taking aripiprazole or clozapine in patients with schizophrenia. Results After taking aripiprazole for 4 weeks, the body weight increased (P <0.05), and no significant changes in blood glucose level. After taking clozapine, body weight (P <0.01), blood glucose (P <0.05) increased significantly at the 4th week, but body weight increased gradually. Conclusions Both aripiprazole and clozapine can lead to weight gain on average, clozapine can cause hyperglycemia, and aripiprazole has no effect on blood glucose.