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目的观察持续性心房颤动(简称房颤)导管消融前后血浆脑钠肽(BNP)水平的变化。方法测定68例持续性房颤且无器质性心脏病患者导管消融术前及术后90 d的血浆BNP水平。结果在导管消融后大于3个月的随访中,12例(18%)患者复发心房扑动或房颤。导管消融后3个月血浆BNP水平由术前(80±17)ng/L降为(27±9)ng/L,与术前比较差异有统计学意义(P<0.01)。12例复发房性心律失常患者中,术后血浆BNP为(44±8)ng/L,而维持窦性心律者术后血浆BNP为(25±8)ng/L,两者差异有统计学意义(P<0.01)。结论持续性房颤导管消融后BNP水平下降,且术后维持窦性心律组BNP水平明显低于复发房性心律失常组。
Objective To observe the changes of plasma brain natriuretic peptide (BNP) levels in patients with persistent atrial fibrillation (AF) before and after catheter ablation. Methods Plasma BNP levels were measured in 68 patients with persistent AF and without organic heart disease before catheter ablation and 90 days after the operation. Results In a follow-up of more than 3 months after catheter ablation, 12 (18%) patients had recurrent atrial flutter or atrial fibrillation. The level of plasma BNP decreased from (80 ± 17) ng / L to (27 ± 9) ng / L at 3 months after catheter ablation, which was significantly different from that before operation (P <0.01). Among 12 patients with recurrent atrial arrhythmias, postoperative plasma BNP was (44 ± 8) ng / L, while postoperative plasma BNP was (25 ± 8) ng / L, with statistical significance Significance (P <0.01). Conclusions The level of BNP decreased after catheter ablation of persistent atrial fibrillation, and the level of BNP in sinus rhythm group was significantly lower than that in recurrent atrial arrhythmia group after operation.