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目的探讨糖化血红蛋白(HbA1C)与尿微量白蛋白(U-mAlb)的检测对早期糖尿病肾病(DN)的诊断价值。方法分别采用金标定量法对69例没有并发症的糖尿病(DM)患者和42例DN患者的HbAlC和U-mAlb进行检测。结果DN组HbAlC、U-mAlb的浓度水平显著高于DM组(P<0.01),HbAlC水平越高,U-mAlb浓度水平亦越高,呈正相关。结论对DM患者进行U-mAlb与HbA1C联和检测有助于早期诊断DN。
Objective To investigate the diagnostic value of glycosylated hemoglobin (HbA1C) and urinary microalbumin (U-mAlb) in early diabetic nephropathy (DN). Methods HbA1c and U-mAlb in 69 patients with DM without diabetes and 42 patients with DN were detected by gold standard method. Results The levels of HbA1C and U-mAlb in DN group were significantly higher than those in DM group (P <0.01). The higher the HbA1C level was, the higher the U-mAlb level was. Conclusion The combination of U-mAlb and HbA1C detection in patients with DM is helpful for the early diagnosis of DN.