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目的探讨结直肠癌患者预防性使用抗生素与术后手术切口感染之间的关系。方法回顾性分析1998年1月至2008年12月期间成都市第一人民医院肛肠科专业组收治880例确诊为结直肠癌的患者的临床资料,按照抗生素使用时间将患者分为≥24 h组(n=401)和<24 h组(n=479),比较2组患者手术切口感染的发生率。结果在有切口感染的患者中,手术时间明显延长(P=0.04),出血量更多(P=0.03),抗生素使用时间更长(P=0.04)。在结肠癌手术中,有、无切口感染的患者其手术时间的差异有统计学意义(P=0.01)。而直肠癌手术中,有、无切口感染的患者其手术时间、出血量以及抗生素使用时间差异无统计学意义(P>0.05)。结论手术时间越长或术中出血越多的患者术后越易发生切口感染,而延长抗生素使用时间并不能降低手术切口感染率。
Objective To investigate the relationship between prophylactic use of antibiotics and postoperative surgical incision infection in patients with colorectal cancer. Methods The clinical data of 880 patients diagnosed as colorectal cancer in the Department of Anorectal, First People’s Hospital of Chengdu from January 1998 to December 2008 were retrospectively analyzed. Patients were divided into ≥24 h groups according to antibiotic use time. (n=401) and <24 h groups (n=479). The incidence of surgical incision infection was compared between the two groups. Results In patients with incision infection, the operation time was significantly longer (P = 0.04), the amount of bleeding was more (P = 0.03), and antibiotic use was longer (P = 0.04). In colon cancer surgery, there was a significant difference in the operation time between patients with and without incision infection (P=0.01). However, there was no significant difference in operation time, blood loss, and antibiotic use time between patients with and without incision infection during rectal cancer surgery (P>0.05). Conclusions The longer the operation time or the more intraoperative hemorrhage, the more postoperative incision infection will occur. However, prolonging the use of antibiotics does not reduce the surgical incision infection rate.