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目的探讨兰索拉唑、生长抑素治疗重症患者合并应激性溃疡出血的疗效。方法 78例重症伴应激性溃疡出血患者,随机分为观察组(40例)和对照组(38例)。观察组使用兰索拉唑和生长抑素治疗,对照组单独使用兰索拉唑治疗,比较两组在治疗12、24、48、72 h内的显效率。结果观察组12、24 h内治疗显效率高于对照组(P<0.05),48 h、72 h内显效率差异无统计学意义(P>0.05),观察组72 h后无效率低于对照组(P<0.05)。结论兰索拉唑联合生长抑素治疗重症合并应激性溃疡出血患者早期疗效显著。
Objective To investigate the efficacy of lansoprazole and somatostatin in the treatment of severe patients with stress ulcer bleeding. Methods A total of 78 patients with severe ulcer bleeding were randomly divided into observation group (40 cases) and control group (38 cases). The observation group was treated with lansoprazole and somatostatin, while the control group was treated with lansoprazole alone. The effective rates of the two groups were compared within 12, 24, 48 and 72 h after treatment. Results The effective rate of treatment in observation group was significantly higher than that in control group (P <0.05) within 12 h and 24 h, but there was no significant difference between 48 h and 72 h in observation group (P> 0.05) Group (P <0.05). Conclusion Lansoprazole combined with somatostatin in the treatment of severe combined with stress ulcer bleeding in patients with early effect was significant.