载脂蛋白apo H-I是HDL的主要载脂蛋白,约占所有载脂蛋白的70%。apoA-I的分子量为27000,由245个氨基酸残基组成的多肽,其羧基端是谷氨酸,氨基端为天门冬氨酸。HDL与卵磷脂胆固醇酰基转移酶(LCAT)共同作用可使胆固醇从细胞表面清除,推测这是HDL抗动脉粥样硬化的主要机制之一。已知apo A-I是LCAT的激活剂,将apo A-I或apo A-I与磷脂加入培养细胞液即有自细胞中清除胆固醇的 Apolipoprotein apo H-I is the major apolipoprotein of HDL, accounting for about 70% of all apolipoproteins. The molecular weight of apoA-I is 27000, which is composed of 245 amino acid residues. The apoA-I has glutamic acid at its carboxy terminus and aspartic acid at its amino terminus. HDL and lecithin cholesterol acyltransferase (LCAT) together to clear cholesterol from the cell surface, speculated that this is one of the main anti-atherosclerosis HDL mechanism. It is known that apo A-I is an activator of LCAT. When apo A-I or apo A-I and phospholipid are added to a cultured cell solution, cholesterol is removed from the cells