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以乙酰乙酸甲(乙)酯为原料,合成了2-(2-氨基噻唑-4-基)-(Z)-甲氧亚氨基乙酸酯的酰胺和亚胺两类共13个衍生物,其中10个化合物未见文献报道,所有化合物的结构均经核磁共振氢谱(1H NMR)、红外光谱(IR)和电喷雾电离质谱(ESI-MS)确证。初步杀菌活性测试结果表明,所有化合物在质量浓度200 mg/L下对6种供试植物病原菌均有不同程度的抑制作用,其中化合物mk-1在200 mg/L下对小麦赤霉病菌Fusarium graminearum的抑制率达81.4%。
A total of 13 derivatives of amide and imine of 2- (2-aminothiazol-4-yl) - (Z) -methoxyiminoacetate were synthesized from methyl acetoacetate Ten compounds were not reported in the literature. The structures of all the compounds were confirmed by 1H NMR, IR and ESI-MS. The preliminary bactericidal activity test results showed that all the compounds had different degrees of inhibition on the six tested plant pathogens at a concentration of 200 mg / L, and the compounds mk-1 at 200 mg / L had the highest inhibitory effect on Fusarium graminearum The inhibition rate reached 81.4%.