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目的观察曲美他嗪短期应用对慢性心力衰竭(CHF)患者炎性因子hs-CRP、IC-6及心功能指标的影响。方法将65例CHF患者随机分成常规治疗组32例和曲美他嗪组33例,曲美他嗪组在常规治疗基础上加用曲美他嗪20mg、3次/d,共6个月。比较两组治疗前后炎性因子hs-CRP、IC-6及心功能指标LVEF、6min步行距离的变化情况。结果 CHF患者hs-CRP、IC-6水平明显高于正常组(P均<0.05);治疗后炎性因子hs-CRP、IL-6水平较治疗前明显降低,治疗后心功能指标LVEF、6min步行距离较治疗前明显改善(P均<0.05);曲美他嗪治疗组上述指标改善更明显(P均<0.05)。结论曲美他嗪短期应用能降低炎性因子水平,改善心功能。
Objective To observe the effect of trimetazidine short-term application of hs-CRP, IC-6 and cardiac function in patients with chronic heart failure (CHF). Methods Thirty-five CHF patients were randomly divided into conventional treatment group (n = 32) and trimetazidine group (n = 33). Trimetazidine group was given trimetazidine 20 mg three times a day for 6 months. The changes of hs-CRP, IC-6, LVEF and 6-m walking distance before and after treatment were compared between the two groups. Results The levels of hs-CRP and IC-6 in CHF patients were significantly higher than those in normal controls (all P <0.05). The levels of hs-CRP and IL-6 in CHF patients were significantly lower than those before treatment, The walking distance was significantly improved compared with those before treatment (all P <0.05). The trimetazidine treatment group improved more significantly (P all <0.05). Conclusion Trimetazidine short-term application can reduce the level of inflammatory cytokines and improve cardiac function.