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目的通过观察伴随不同程度颈动脉硬化的急性脑梗死患者血浆Apelin的水平,分析Apelin与动脉粥样硬化及脑梗死发生的相关性。方法选取2015年9月-2016年6月间某院神经内科病房动脉化性脑梗死的患者98例,健康人35例,所有病例经颈部血管超声检查根据颈动脉内膜中层厚度分组,测定各组血浆Apelin水平。同时对比组间身高、体重、血压、血糖、血脂等指标及血浆一氧化氮和颈动脉超声指标变化。分析急性脑梗死患者血浆Apelin水平的含量变化及其与一般情况、动脉硬化程度的相关性。结果各组血浆Apelin水平有显著性差异,内膜正常组高于内膜增厚组、斑块形成组和血管狭窄组,内膜增厚组高于斑块形成组和血管狭窄组,斑块形成组高于血管狭窄组;各组血浆一氧化氮水平有显著性差异,内膜正常组高于内膜增厚组、斑块形成组和血管狭窄组,内膜增厚组高于斑块形成组和血管狭窄组,斑块形成组高于血管狭窄组;血浆Apelin水平与收缩压、总胆固醇、低密度脂蛋白、颈动脉内层中膜厚度呈负相关,与血浆一氧化氮呈正相关;血浆一氧化氮水平与收缩压、总胆固醇、低密度脂蛋白、颈动脉内层中膜厚度呈负相关,与血浆Apelin呈正相关。结论血浆Apelin在脑梗死急性期表现为下降,血浆Apelin可能与一氧化氮共同参与了动脉粥样硬化的发生发展和急性脑梗死的发病的病理过程。
Objective To observe the correlation between Apelin and atherosclerosis and cerebral infarction by observing the level of plasma Apelin in patients with acute cerebral infarction with varying degrees of carotid atherosclerosis. Methods From September 2015 to June 2016, 98 patients with arterial cerebral infarction in a hospital ward neurology department and 35 healthy people were selected. All cases were divided into two groups based on carotid artery intima-media thickness Plasma Apelin levels in each group. At the same time, the changes of height, weight, blood pressure, blood glucose, blood lipids and other indexes of plasma nitric oxide and carotid artery were compared between the two groups. To analyze the changes of plasma Apelin levels in patients with acute cerebral infarction and its correlation with the general situation and the degree of atherosclerosis. Results There was a significant difference in plasma Apelin levels in each group. The intima-normal group was higher than intima-thickening group, plaque-forming group and vascular stenosis group. Intimal thickening group was higher than plaque-forming group and vascular stenosis group. Forming group higher than vascular stenosis group; plasma nitric oxide levels in each group were significantly different, normal intimal group than intimal thickening group, plaque formation group and vascular stenosis group, intimal thickening group was higher than the plaque The level of plasma Apelin was negatively correlated with systolic blood pressure, total cholesterol, low density lipoprotein, carotid artery intima-media thickness, and plasma nitrogen monoxide formation in group and stenosis group. ; Plasma nitric oxide levels and systolic blood pressure, total cholesterol, low density lipoprotein, carotid artery intima media thickness was negatively correlated with plasma Apelin was positively correlated. Conclusions Plasma Apelin is decreased in the acute phase of cerebral infarction. Plasma Apelin may be involved in the development of atherosclerosis and the pathogenesis of acute cerebral infarction with nitric oxide.