综述Hippospongia属海绵的化学成分及生物活性。该属海绵次生代谢产物丰富,富含萜类、长链脂肪族类及甾体类化合物,且具有独特的生物活性,包括抗肿瘤、对DNA聚合酶β和HIV逆转录酶抑制作用及冠状血管舒张等作用,具有广阔的开发应用前景。对该属海绵化合物类型进行分类归纳,并对其药理活性研究进行综述,为该属海绵进一步研究开发提供参考。 The chemical composition and biological activity of Hippospongia are summarized. This sponge is rich in secondary metabolites, rich in terpenoids, long chain aliphatic and steroidal compounds, and has unique biological activity, including anti-tumor, inhibition of DNA polymerase beta and HIV reverse transcriptase, and coronary Vasodilation and other effects, has broad prospects for the development and application. The genus sponge compounds were classified and summarized, and their pharmacological activities were reviewed, providing references for the further research and development of this genus sponge.