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目的探讨凯因益生伴侣颗粒联合干扰素α-2b治疗慢性乙型肝炎的临床疗效。方法选取2012年2月—2013年2月在邯郸市传染病医院接受治疗的慢性乙型肝炎患者120例,随机分为干预组和对照组,各60例。对照组在基础保肝、降酶支持对症治疗的基础上给予重组人α-2b干扰素治疗,干预组在对照组基础上给予凯因益生伴侣颗粒治疗,检测并比较两组患者的肝功能指标、血清HBs Ag水平、血清HBV-DNA水平、血清HBe Ag/HBe Ab转换率。结果治疗12周后干预组的谷氨酸氨基转移酶(ALT)、天冬氨酸氨基转移酶(AST)、总胆红素(TBi L)低于对照组,差异有统计学意义(P<0.05)。治疗后4周、8周、12周干预组血清HBs Ag水平、血清HBV-DNA水平低于对照组,差异有统计学意义(P<0.05)。治疗后两组不同血清HBs Ag水平的患者血清HBe Ag/HBe Ab转换率比较,差异无统计学意义(P>0.05);治疗后12周,干预组血清HBe Ag/HBe Ab转换率高于对照组,差异有统计学意义(P<0.05)。结论凯因益生伴侣颗粒联合干扰素是慢性乙型肝炎抗病毒治疗的有效药物,与单纯干扰素用药相比,具有明显的改善患者肝功能、降低血清HBs Ag水平及血清DNA水平、降低血清HBe Ag/HBe Ab转换率的效果。
Objective To investigate the clinical efficacy of Cain probiotics granule combined with interferon α-2b in the treatment of chronic hepatitis B patients. Methods 120 patients with chronic hepatitis B who were treated in Handan Infectious Disease Hospital from February 2012 to February 2013 were randomly divided into intervention group and control group, with 60 cases in each group. The control group was treated with recombinant human α-2b interferon on the basis of basing on liver protection and reducing enzyme support symptomatic treatment. The intervention group was treated with Keain probiotics partner granulation on the basis of control group. The liver function indexes of two groups were detected and compared , Serum HBsAg level, serum HBV-DNA level, serum HBe Ag / HBe Ab conversion rate. Results After 12 weeks of treatment, the levels of ALT, AST and TBi in the intervention group were lower than those in the control group (P < 0.05). Serum levels of HBsAg and serum HBV-DNA levels were lower in intervention group than in control group at 4, 8 and 12 weeks after treatment (P <0.05). There was no significant difference in the conversion rate of serum HBe Ag / HBe Ab between two groups of patients with different serum HBs Ag levels (P> 0.05). After 12 weeks of treatment, the conversion rate of serum HBeAg / HBe Ab in intervention group was higher than that of control Group, the difference was statistically significant (P <0.05). Conclusion Cain probiotics granule combined with interferon is an effective drug for the treatment of chronic hepatitis B antiviral therapy. Compared with interferon alone, the combination of Cain’s probiotics and interferon can significantly improve liver function, reduce serum HBsAg and serum DNA levels, and decrease serum HBe Effect of Ag / HBe Ab conversion rate.