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目的对替米沙坦联合丹参川芎嗪治疗糖尿病肾病的临床效果进行观察。方法选取本院自2011年3月~2013年3月收治的90例糖尿病肾病患者随机分为甲组、乙组与丙组,各为30例,甲组采用替米沙坦联合丹参川芎嗪治疗,乙组及丙组分别采用替米沙坦、丹参川芎嗪治疗,观察三组患者治疗前后24 h尿白蛋白排泄量、血压、血糖、尿素氮、尿酸、低密度脂蛋白、高密度脂蛋白等指标,比较治疗总有效率及不良反应发生率。结果三组患者治疗后尿白蛋白排泄量均有明显下降(P<0.05),甲组患者血压、血肌酐、血清白蛋白等指标均明显优于乙组、丙组(P<0.05);甲组患者治疗总有效率为93.3%,乙组患者治疗总有效率为73.3%,丙组患者治疗总有效率为70%,甲组与乙组、丙组比较差异有统计学意义(P<0.05);三组患者不良反应发生比较差异无统计学意义(P>0.05)。结论替米沙坦联合丹参川芎嗪治疗糖尿病肾病能够有效改善血液流变学指标,减少白蛋白排泄量,促进患者康复,值得推广使用。
Objective To observe the clinical effect of telmisartan and ligustrazine tetramethylpyrazine in the treatment of diabetic nephropathy. Methods Ninety patients with diabetic nephropathy who were treated in our hospital from March 2011 to March 2013 were randomly divided into group A, group B and group C, each with 30 cases. Group A was treated with telmisartan and ligustrazine plus ligustrazine , Group B and group C were treated with telmisartan and ligustrazine respectively. The levels of urinary albumin excretion, blood pressure, blood glucose, urea nitrogen, uric acid, low density lipoprotein, high density lipoprotein And other indicators, the total effective rate of treatment and adverse reaction rates. Results The urinary albumin excretion decreased significantly in all three groups (P <0.05). The blood pressure, serum creatinine and serum albumin in group A were significantly better than those in group B and group C (P <0.05). The total effective rate was 93.3% in group A, 73.3% in group B and 70% in group C. The difference between group A and group B was statistically significant (P <0.05 ). There was no significant difference in adverse reactions between the three groups (P> 0.05). Conclusion Telmisartan combined with Salvia miltiorrhizae ligustrazine in the treatment of diabetic nephropathy can effectively improve the indexes of hemorrheology, reduce the albumin excretion and promote the rehabilitation of patients, which deserved to be widely used.